Basic clinical-pathological correlation in AD 

 
   Lead Investigator:    Peter Nelson
   Institution      :    University of Kentucky
   E-Mail           :    peter.nelson@uky.edu
   Proposal ID      :    105


   Publications:


1  Nelson P
   Sexually Dimorphic Mir-497 Regulates Alpha-Synuclein And Alpha-Synucleinopathy
   41542   Grant  NIH/NINDS   R21 NS085830   , 

   FUNDED



2  Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, Hyman BT, Iwatsubo T, Jellinger KA, Jicha GA, Kovari E,  Kukull WA , Leverenz JB, Love S, Mackenzie IR, Mann DM, Masliah E, McKee AC, Montine TJ, Morris JC, Schneider JA, Sonnen JA, Thal DR, Trojanowski JQ, Troncoso JC, Wisniewski T, Woltjer RL, Beach TG
   Correlation of Alzheimer's Disease Neuropathologic Changes with Cognitive Status: a Review of the Literature
   Journal Article  J Neuropathol Exp Neurol,71:362-381,2012,PMC3560290

   PUBLISHED



3  Nelson PT, Head E, Schmitt FA, Jicha GA, Abner E, Smith CD, Van Eldik LJ, Kryscio RJ, Scheff SW
   Alzheimer's disease is not ^{unicode 201d}brain aging^{unicode 201c}: neuropathological, genetic, and epidemiological human studies
   Journal Article  Acta Neuropathol,121:571-587,2011,PMC3179861

   PUBLISHED



4  Nelson PT, Schmitt FA, Lin Y, Abner EL, Jicha GA, Patel E, Thomason PC, Neltner JH, Smith CD, Santacruz KS, Sonnen JA, Poon LW, Gearing M, Green RC, Woodard JL, Van Eldik LJ, Kryscio RJ
   Hippocampal sclerosis in advanced age: clinical and pathological features
   Journal Article  Brain,134:1506-1518,2011,PMC3097889

   PUBLISHED





   Proposal Description:
   We intend to perform clinical-pathological correlation experiments that are relatively similar methodologically with the prior 5 published experiments performed using NACC data along with particular data from the UK-ADC.  We hypothesize that with increased age there is more cerebrovascular disease and hippocampal sclerosis and less AD pathology.  This would also show more individuals dying with Braak stage V neurofibrillary pathology.  This is an important and should move the field forward because there currently is much confusion about clinical-pathological correlation in older persons.  We may be able to publish two different papers--one related to hippocampal sclerosis and one related to Braak stage V pathology.  The NACC dataset provides an ideal context to study this issue.